I upgraded to Linux Mint 18 this week (based on Ubuntu 16.04) and re-setup my entire home server. This system uses systemd, and I wanted to use it to start YACReaderLibraryServer. The cron method posted by selmf was not sufficient for my purposes, because I needed to make sure that the ZFS shared directory with my library was mounted before YAC starts. The service file below seems to be working ok, so I thought I would ask for feedback and share what worked for me.

Looks good to me. One thing you could consider to add is directory access restriction for increased security. If you keep all your comics in one place the server only needs access to that directory and /home/user/.local/share/YACReader to work.